The Palace of Carlos V in Granada , is a Renaissance building on the hill of the Alhambra. Since 1958, it houses the Museo de Bellas Artes de Granada.

It was built by King Carlos I (Emperor of the Holy Roman Empire under the name of Charles V) from his marriage to Isabel of Portugal , held in Seville in 1526. After the wedding, the couple was living several months in the Alhambra, being deeply impressed by the palace, leaving in charge the construction of the new palace with the intention of establishing residence in the Alhambra in Granada. And the Catholic Kings had wards after 1492, but the intention of Charles was to acquire a stable residence to the extent of an emperor. The project was assigned to Pedro Machuca, extraordinary figure that history has not been able to explain to solvency. In a Spain in which the prevailing style was plateresco, and that was not totally off the Gothic, Machuca built a palace which corresponds stylistically to Mannerism, a style that was taking its first steps in Italy. Even accepting the versions that place Machuca in the workshops of Michelangelo, when they begin work on the Palace in 1527 he had not yet taken as representative of his architectural production.